Importance of Beta Cell Function for the Treatment of Type 2 Diabetes
نویسنده
چکیده
Type 2 diabetes (T2DM) is characterized by insulin resistance and beta cell dysfunction. Recent evidence has emerged that beta cell dysfunction is a common pathogenetic feature of both type 1 and type 2 diabetes, and T2DM never develops without beta cell dysfunction. Therefore, treatment of T2DM should aim to restore beta cell function. Although the treatment of T2DM has greatly improved over the past few decades, remaining issues in the current treatment of T2DM include (1) hypoglycemia; (2) body weight gain; (3) peripheral hyperinsulinemia and (4) postprandial hyperglycemia, which are all associated with inappropriate insulin supplementation, again underpinning the important role of endogenous and physiological insulin secretion in the management of T2DM. This review summarizes the current knowledge on beta cell function in T2DM and discusses the treatment strategy for T2DM in relation to beta cell dysfunction.
منابع مشابه
Effects of Aerobic Training on mTORC1 Gene Expression in Male Wistar Rats with Type 2 Diabetes
Objective: Although type 2 diabetes is a multifactorial illness, one of the major risk factors is the prevalence of obesity.In this context, recent genetic studies on diabetics or pre-diabetics, have shown that some of the newly-known genes make the conditions for type 2 diabetes even in the absence of obesity. One of these genes is called mTORC1, which plays an important role in the synt...
متن کاملارتباط بین گرلین سرم با شاخص عملکرد سلولهای بتا و مقاومت به انسولین در افراد مبتلا به دیابت نوع دو
Background and purpose: Çonsiderable attention has recently been paid to the role of ghrelin hormone in the metabolism of carbohydrate. Beta-cell dysfunction is also considered to be an important factor in the prevalence of diabetes. This study aimed at investigating the relationship between serum ghrelin with beta-cell function and insulin resistance in type 2 diabetic patients. Materials...
متن کاملTreatment effect of GABA on improve type one diabetes in NOD mice
Introduction: Gama amino butyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian nervous system. The concentration of GABA and the number of GABA cell secretion decrease in diabetic patient and experimental diabetes model. The reported effects of GABA activation on insulin secretion from beta cells have been controversial. In this study we investigated if GABA administr...
متن کاملEffects of High Intensity Interval Training and Combined Training on Serum Apelin Levels and pancreatic β-cell function in Overweight Type 2 Diabetes Women
Objective: Physical exercise is a well-established therapeutic method in type 2 diabetes treatment. The purpose of this study was to investigate the effects of eight weeks combined and High Intensity Interval Training on serum apelin levels and pancreatic β-cell function in overweight women with type 2 diabetes mellitus. Materials and Methods: Fifty-two overweight female patients with type 2 d...
متن کاملThe role of noggin in regulation of high glucose-induced apoptosis and insulin secretion in INS-1 rat beta cells
Objective(s):The purpose of this study was to investigate the effects of Noggin on high glucose-induced apoptosis and insulin secretion in pancreatic beta cells. Materials and Methods: Different concentrations of glucose were used to examine their effects on INS-1 rat beta cells in vitro. When specific siRNA targeting Noggin and recombinant Noggin were added, apoptosis and insulin secretion wer...
متن کاملEffect of 12 Weeks Aerobic Training on FOXO1 Gene Expression in Pancreatic Tissue of Type 2 Diabetes Wistar Rats
Objective: Exercise as a non-pharmacological treatment plays an important role in regulating and reducing the inflammatory cytokine associated with beta cell function. Genetics is one of the most important and effective factors in the incidence of diabetes, in most cases. The present study aims to explain the effect of 12 weeks aerobic training on FOXO1 expression in pancreatic tissue, insulin ...
متن کامل